Acetic Acid → HCID 19898798, compound

Participants

Reaction Steps

A stirred mixture of 32.5 g (0.11 mole) of 2-(4-methylphenyl)pyrazolo[1,5-a]pyrimidine-3-acetic acid ethyl ester and 4.5 g (0.11 mole) of sodium hydroxide in 150 mL of 190 ethanol was heated until the material dissolved. After cooling, the reaction mixture was diluted with an equal volume of water, heated until a clear dark brown solution was obtained, then cooled by stirring overnight. The reaction mixture was diluted with an additional 300 mL of water and acidified to pH 6 with glacial acetic acid. The milky solution yielded 27 g (90%) of brown crystalline product, mp 170°-171°. An analytical sample recrystallized from acetonitrile-water yielding pale yellow crystals, mp. 172°-173° C.

Provenance & Evidence