Benzene → HCID 19898819, compound

Participants

Reaction Steps

A mixture of 3.25 g (0.010 mole) of 3-[2-(1H-imidazole-1-yl)-2-oxoethyl]-2-(4-methylphenyl)pyrazolo[1,5-a]pyrimidine (prepared from 2-(4-methylphenyl)pyrazolo[1,5-a]pyrimidine-3-acetic acid and 1,1'-carbonyldiimidazole) and 1.1 g (0.011 mole) of dipropylamine in 25 ml of benzene was stirred at reflux for 5 hours. After cooling, the reaction mixture was washed with water, dried over magnesium sulfate, and concentrated in vacuo (2.6 g). The crude solid residue was purified by a liquid-solid extraction with isopropyl ether in a soxhlet. The purified product was collected by filtration from the isopropyl ether (extraction solvent) to yield 1.4 g (39.6%) of golden yellow crystals, mp 110°-111° C.

Provenance & Evidence