Methylamine → HCID 19898806, compound

Participants

Reaction Steps

A stirred slurry of 3.2 g (0.010 mole) of 3-[2-(1H-imidazole-1-yl)-2-oxoethyl]-2-(4-methylphenyl)pyrazolo[1,5-a]pyrimidine (prepared from 2-(4-methylphenyl)pyrazolo[1,5-a]pyrimidine-3-acetic acid and 1,1'-carbonyldiimidazole) in 20 ml of dry tetrahydrofuran was treated with 3 ml of monomethylamine in 10 ml of dry tetrahydrofuran added dropwise from a needle and syringe. After stirring for 36 hours the reaction mixture was diluted with 100 ml of water and the resulting solid collected by filtration (1.7 g). The crude product was recrystallized from acetonitrile to yield 1.1 g (38.9%) of beige crystals, mp 207°-208° C.

Provenance & Evidence