Ammonia → HCID 9903432, compound

Participants

Reaction Steps

A stirred slurry of 3.2 g (0.010 mole) of 3-[2-(1H-imidazole-1-yl)-2-oxoethyl]-2-(4-methylphenyl)pyrazolo[1,5-a]pyrimidine (prepared from 2-(4-methylphenyl)pyrazolo[1,5-a]pyrimidine-3-acetic acid and 1,1'-carbonyldiimidazol) in 20 ml of dry tetrahydrofuran was treated with 3 ml of ammonia in 10 ml of dry tetrahydrofuran. After stirring for 16 hours, the reaction mixture was diluted with 100 ml of water and the precipitated solid collected by filtration (1.6 g). The crude product was recrystallized from acetonitrile to yield 1.1 g (40.9%) of pale yellow crystals, mp 225°-226° C.

Provenance & Evidence