Dimethylamine → HCID 19898797, compound

Participants

Reaction Steps

A stirred slurry of 3.2 g (0.010 mole) of 3-[2-(1H-imidazole-1-yl)-2-oxoethyl]-2-(4-methylphenyl)pyrazolo[1,5-a]pyrimidine (prepared from 2-(4-methylphenyl)pyrazolo[1,5-a]pyrimidine-3-acetic acid and 1,1'-carbonyldiimidazole) in 20 ml of dry tetrahydrofuran was treated with 3 ml of dimethylamine in 10 ml of dry tetrahydrofuran. After stirring for 16 hours, the reaction mixture was diluted with 100 ml of water and the precipitated solid collected by filtration (1.4 g). The crude product was purified by a liquid-solid extraction in a soxhlet using isopropyl ether as the extracting solvent. Filtration yielded 1.6 g (33.6%) of golden yellow crystals, mp 163.5°-165° C.

Provenance & Evidence