Hydrochloric Acid → 2-(Chloromethyl)-4-phenylpyridine--hydrogen chloride (1/1)

Participants

Reaction Steps

A solution of 4-phenyl-2-pyridinemethanol (1.57 g) in ether (5 ml) was treated with ethereal hydrogen chloride (ca 5 ml). The resulting solid was filtered off and added to redistilled thionylchloride (7.5 ml) at ca 0°. The brown solution was stirred at ca 0° for 2 h and at 22° for 0.5 h. Ether (100 ml) was added and the resulting solid was filtered off to give the title compound as a solid (1.81 g). T.l.c. Silica (Dichloromethane, ethanol and ammonia 200:8:1) Rf 0.7.

Provenance & Evidence