HuagongsheHuagongshe Chemistry Print Report · For research reference only
1,1'-Carbonyldiimidazole → HCID 10708152, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1,1'-Carbonyldiimidazole | HCID 68263 | — |
| Reactant | (2S)-2-amino-3-(1H-indol-3-yl)-N-methylpropanamide | HCID 14505575 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | HCID 10708152 | HCID 10708152 | 67% |
Reaction Steps
The hydrochloride salt of L-tryptophan 2-hydroxyethylamide was prepared and coupled with 3 as described for the hydrochloride salt of L-tryptophan methylamide in Example 1 except that 3 was activated with 1,1'-carbonyldiimidazole for 20 minutes in methylene chloride at room temperature. The crude product was a mixture of 0.7 g (67% yield) of the diastereoisomers 12A,B: Rf (C) 12A 0.38, Rf (C) 12B 0.19.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05114953 |
| Source dataset | uspto-grants-1992_05 |
| ORD ID | ord-0e92efa5d85648fabda19c93434a0dfc |
| Source note | uspto-grants-1992_05 |