HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methylamine → 2-(4-Methyl-2H-phthalazin-1-on-2-yl)-N-methylethylamine hydrobromide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methylamine | HCID 6329 | — |
| Reactant | 2-(2-Bromoethyl)-4-methylphthalazin-1(2H)-one | HCID 21761486 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 2-(4-Methyl-2H-phthalazin-1-on-2-yl)-N-methylethylamine hydrobromide | HCID 19898933 | — |
Reaction Steps
2-(4-Methyl-2H-phthalazin-1-on-2-yl)ethyl bromide (6.1 g) and methylamine (20 ml of 30% ethanolic methylamine) in ethanol (150 ml) were heated in a bomb at 100° for 2 hours. The solvent was removed and the residue triturated with ethyl acetate to give a yellow solid, which was recrystallised from ethanol to afford the title compound, yield 5.03 g, m.p. 219°-221°.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05114952 |
| Source dataset | uspto-grants-1992_05 |
| ORD ID | ord-ffcfb01f686d4b679e8a92ca309b9900 |
| Source note | uspto-grants-1992_05 |