HuagongsheHuagongshe Chemistry Print Report · For research reference only
Indole → 3-Chloroquinoline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Indole | HCID 798 | — |
| Reactant | Chloroform | HCID 6212 | — |
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Catalyst | Benzyl triethylammonium chloride | HCID 66133 | — |
| Product | 3-Chloroquinoline | HCID 69164 | — |
Reaction Steps
Indole (ex Aldrich) was reacted with chloroform and aqueous sodium hydroxide in the presence of triethylbenzyl ammonium chloride to give 3-chloroquinoline (cf. Sundo et al, Synthesis, 4, 249 (1976). The latter was converted to 2,3-dichloroquinoline, as for Example VII.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05114940 |
| Source dataset | uspto-grants-1992_05 |
| ORD ID | ord-da0338e5eb1849c4820c4b306b4d2b38 |
| Source note | uspto-grants-1992_05 |