Methyl 2,2-dichloro-2-fluoroacetate → HCID 86745843, compound

HRID 1196561Notes

Reaction equation

HRID 1196561 reaction equation
[F:1]/[C:2](=[CH:5]\[CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][O:13][C:14]1[CH:23]=[CH:22][C:21]2[C:16](=[CH:17][CH:18]=[CH:19][CH:20]=2)[N:15]=1)/[CH:3]=O.Cl[C:25](Cl)([F:30])[C:26]([O:28][CH3:29])=[O:27]>>[F:30]/[C:25](=[CH:3]\[C:2](\[F:1])=[CH:5]\[CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][O:13][C:14]1[CH:23]=[CH:22][C:21]2[C:16](=[CH:17][CH:18]=[CH:19][CH:20]=2)[N:15]=1)/[C:26]([O:28][CH3:29])=[O:27]

Participants

3

Reactant 2

HCID 13612258Methyl 2,2-dichloro-2-fluoroacetateHCID 22844007HCID 22844007, compound2×

Product 1

HCID 86745843HCID 86745843, compound

Procedure

(Z)-2-Fluoro-10-(2-quinolinyloxy)dec-2-ene-1-al, prepared as in compound 45 was reacted with methyl dichlorofluoroacetate as in compound 40 to give (2Z,4Z) methyl 2,4-difluoro-12-(2-quinolinyloxy)dodeca-2,4-dienoate. The latter was converted to the title compound an analogy with compound 33.

Sources & evidence

ORD record
ord-765f89062f1445b0b9e15927b63ca926
Source dataset
uspto-grants-1992_05
Patent number
US05114940

Reaction notes

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