Aniline → HCID 178516132, compound

Participants

Reaction Steps

Ethyl trifluoroacetoacetate (3.7 g) and aniline (1.8 ml) were reacted together in polyphosphoric acid according to Joullie et al, J. Med. Chem., 16, 134 (1973), to give 2-trifluoromethyl-4-hydroxyquinoline (1.8 g). The latter was reacted with phosphorous oxychloride and phosphorous pentachloride in a similar fashion to Example VIII to give 2-trifluoromethyl-4-chloroquinoline, which was used in Stage a.

Provenance & Evidence