Ethyl chloroformate → HCID 135444596, compound

Participants

Reaction Steps

To a room temperature solution of 2-(2,6-dichloro-3-methylanilino)benzamide oxime (585 mg, 1.89 mmols) in 5 mL of pyridine is added ethyl chloroformate (250 μL, 2.62 mmols). The solution is heated at reflux for 1 hour, cooled, and concentrated in vacuo. Flash chromatography eluting with 2:1 hexane: ethyl acetate provides 295 mg (47%) of 3-[2-[(2,6-dichloro-3-methylphenyl)amino]phenyl]-1,2,4-oxadiazol-5(4H)-one as a white solid;

Provenance & Evidence