HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetyl chloride → 4-Chloro-2-methyl-1-oxo-1lambda~5~-pyridine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetyl chloride | HCID 6367 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | Pyridine, 2-methyl-4-nitro-, 1-oxide | HCID 95291 | — |
| Product | 4-Chloro-2-methyl-1-oxo-1lambda~5~-pyridine | HCID 12211801 | — |
Reaction Steps
15.4 g (0.1 mol) of 4-nitro-2-picoline-N-oxide are added in portions at 0° C. to 75 ml of acetyl chloride. On warming to room temperature, a clear solution results which is added dropwise to ice with stirring. After adding K2CO3, the mixture is extracted several times using dichloromethane and ethyl acetate. After evaporating, the product is purified chromatographically on silica gel. The oil obtained crystallizes on standing, m.p. 37° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05114955 |
| Source dataset | uspto-grants-1992_05 |
| ORD ID | ord-0e9510eff730453db6f28636110286eb |
| Source note | uspto-grants-1992_05 |