Potassium Iodide → HCID 19899238, compound

Participants

Reaction Steps

83 g of pulverised potassium carbonate and 4 g of of finely powdered potassium iodide are added to a solution of 94.1 g of 4-(4-fluorophenoxy)phenol in 400 ml of methyl ethyl ketone, and the mixture is heated to reflux temperature. With stirring, 64 g of freshly distilled chloroacetone are added dropwise over 1 hour, and the reaction mixture is stirred for a further 2 hours at reflux temperature. After cooling, the reaction mixture is filtered and the solvent is removed by vacuum distillation. The crude product is recrystallised from n-hexane/diethyl ether (5:1), to give the pure, colourless 1-[4-(4-fluorophenoxy)phenoxy]-2-propanone which melts at 56°-57° C.

Provenance & Evidence