Potassium Hydroxide → HCID 19899011, compound

Participants

Reaction Steps

2.5 of methyl 3-(4-chlorophenyl)-5,6,7,8-tetrahydro-4H-cyclohept[d]isoxazole-6-carboxylate in 20 ml of methanol were treated with 1.5 g of potassium hydroxide in 2 ml water at 20° C. for 16 hours. After removing the methanol by evaporation, the residue was taken up in water. The aqueous-alkaline solution was washed with diethyl ether, acidified with 2N hydrochloric acid and extracted with diethyl ether. After drying over magnesium sulfate and evaporation, there were obtained 1.8 g of 3-(4-chlorophenyl)-5,6,7,8-tetrahydro-4H-cyclohept[d]isoxazole-6-carboxylic acid of melting point 144°-145° C. after recrystallization from ethyl acetate/hexane.

Provenance & Evidence