Potassium Hydroxide → HCID 19899000, compound

Participants

Reaction Steps

2,48 g of methyl 3-(4-chlorophenyl)-5,6,7,8-tetrahydro-4H-cyclohept[d]isoxazole-7-carboxylate were treated with 0.8 g of potassium hydroxide in 2 ml of water and 50 ml of methanol at 20° C. Methanol was removed from the mixture by evaporation and the residue was taken up in water. After washing with diethyl ether, the aqueous alkaline solution was acidified with 2N hydrochloric acid and extracted with diethyl ether. The ethereal extract was dried over magnesium sulfate and evaporated to give 1.9 g of 3-(4-chlorophenyl)-5,6,7,8-tetrahydro-4H-cyclohept[d]-isoxazole-7-carboxylic acid of melting point 215°-217° C. (from methanol).

Provenance & Evidence