反应详情

7.7 g of diethyl 3-(4-chlorophenyl)-4,5,6,7-tetrahydro-1,2-benzisoxazole-5,5-dicarboxylate were treated with 2.74 g of potassium hydroxide in 16 ml of water and 65 ml of ethanol at 20° C. for 3 days. After removal of the ethanol by evaporation and acidification with 2N hydrochloric acid, the product was taken up in ethyl acetate. There were obtained 6.7 g of 3-(4-chlorophenyl)-4,5,6,7-tetrahydro-1,2-benzisoxazole-5,5-dicarboxylic acid as a buff colored solid of melting point 200°-202° C. (decomposition).

1. customAfter removal of the ethanol
2. customby evaporation and acidification with 2N hydrochloric acid