Potassium Hydroxide → HCID 67896149, compound

HRID 1196659Notes

Reaction equation

HRID 1196659 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[C:12]3[CH2:13][C:14]([C:22]([O:24]CC)=[O:23])([C:17]([O:19]CC)=[O:18])[CH2:15][CH2:16][C:11]=3[O:10][N:9]=2)=[CH:4][CH:3]=1.[OH-].[K+]>O.C(O)C>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[C:12]3[CH2:13][C:14]([C:17]([OH:19])=[O:18])([C:22]([OH:24])=[O:23])[CH2:15][CH2:16][C:11]=3[O:10][N:9]=2)=[CH:4][CH:3]=1

Participants

5

Reactant 2

HCID 14797Potassium HydroxideHCID 67896181HCID 67896181, compound

Product 1

HCID 67896149HCID 67896149, compoundYield 102.2%

Reagents, catalysts & solvents 2

HCID 702EthanolSolventHCID 962WaterSolvent

Procedure

7.7 g of diethyl 3-(4-chlorophenyl)-4,5,6,7-tetrahydro-1,2-benzisoxazole-5,5-dicarboxylate were treated with 2.74 g of potassium hydroxide in 16 ml of water and 65 ml of ethanol at 20° C. for 3 days. After removal of the ethanol by evaporation and acidification with 2N hydrochloric acid, the product was taken up in ethyl acetate. There were obtained 6.7 g of 3-(4-chlorophenyl)-4,5,6,7-tetrahydro-1,2-benzisoxazole-5,5-dicarboxylic acid as a buff colored solid of melting point 200°-202° C. (decomposition).

Workup

  1. customAfter removal of the ethanol
  2. customby evaporation and acidification with 2N hydrochloric acid

Sources & evidence

ORD record
ord-ec9796f4b60947cd8bb751c2c94ff366
Source dataset
uspto-grants-1992_05
Patent number
US05114960

Reaction notes

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