HuagongsheHuagongshe Chemistry Print Report · For research reference only
HCID 19899041, compound → HCID 19898995, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | HCID 19899041 | HCID 19899041 | — |
| Solvent | Hydrochloric Acid | HCID 313 | — |
| Product | HCID 19898995 | HCID 19898995 | 52.9% |
Reaction Steps
A solution of 0.59 g of ethyl 3-(4-chlorophenyl)-3a,4,5,6,7,7a-hexahydro-7a -pyrrolidino-1,2-benzisoxazole-6-carboxylate (mixture of two diastereoisomers) in 25 ml of 2N hydrochloric acid was heated under reflux for 4 hours. After 1 hour, 0.332 g of a crystalline acid separated out. Crystallization from ethyl acetate/toluene gave 0.23 g of 3-(4-chlorophenyl)-4,5,6,7-tetrahydro-1,2-benzisoxazole-6-carboxylic acid of melting point 227°-228° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05114960 |
| Source dataset | uspto-grants-1992_05 |
| ORD ID | ord-73dffb8a582b48ac81492a2df0e3e6b5 |
| Source note | uspto-grants-1992_05 |