HCID 67896192, compound → HCID 19899043, compound

Participants

Reaction Steps

A solution of 9.1 g of methyl 3-(4-chlorophenyl)-3a,4,5,6,7,7a -hexahydro-6-methyl-7a-pyrrolidino-1,2-benzisoxazole-6-carboxylate in 100 ml of 2N hydrochloric acid was heated under reflux for 6 hours. The product which separated on cooling was extracted with ethyl acetate and the ethyl acetate extract was dried over magnesium sulfate and evaporated. After crystallization from ethyl acetate/hexane there was obtained 5.3 g of 3-(4-chlorophenyl)-4,5,6,7-tetrahydro-6-methyl-1,2-benzisoxazole-6-carboxylic acid of melting point 185°-187° C.

Provenance & Evidence