HCID 67895931, compound → HCID 67896177, compound

Participants

Reaction Steps

A solution of 4.7 g (12 mmol) of methyl 3-(4-chlorophenyl)-6-ethyl-3a,4,5,6,7,7a-hexahydro-7a-pyrrolidino-1,2-benzisoxazole-6-carboxylate in 200 ml of 2N hydrochloric acid was heated under reflux for 6 hours. The mixture was extracted with diethyl ether and the extracts were dried over magnesium sulfate and evaporated. After crystallization from methylcyclohexane, there were obtained 1.58 g of methyl 3-(4-chlorophenyl)-6-ethyl-4,5,6,7-tetrahydro-1,2-benzisoxazole-6-carboxylate of melting point 101°-102.5° C.

Provenance & Evidence