Water → HCID 19898999, compound

Participants

Reaction Steps

2.4 g (0.039 mol) of methyl 3-(4-chlorophenyl)-4,5,6,7,8,9-hexahydrocyclooct[d]isoxazole-8-carboxylate were stirred for 18 hours in 10 ml of methanol, 0.5 g of potassium hydroxide and 2 ml of water. The methanol was removed by evaporation and the residual gum was dissolved in water. Acidification with a few drops of concentrated hydrochloric acid gave a white granular precipitate which was filtered off, washed with water and dried. After crystallization from glacial acetic acid, there were obtained 1.9 g of 3-(4-chlorophenyl)-4,5,6,7,8,9-hexahydrocyclooct[d]isoxazole-8-carboxylic acid of melting point 215° C.

Provenance & Evidence