HCID 19899116, compound → HCID 19899111, compound

Participants

Reaction Conditions

Reaction Steps

5 g (0.012 mol) of methyl 3-(3,4-dichlorophenyl)-3a,5,6,7,8,8a-hexahydro-8a-pyrrolidino-4H-cyclohept[d]isoxazole-7-carboxylate were dissolved in a mixture of 5 ml of water, 5 ml of concentrated sulfuric acid and 5 ml of glacial acetic acid and heated at 120° C. for 1.5 hours. The mixture was cooled, whereupon the crystals which formed were filtered off and washed firstly with glacial acetic acid and then with water. After drying in a vacuum and crystallization from methanol, there was obtained 0.7 g of 3-(3,4-dichlorophenyl)-5,6,7,8-tetrahydro-4H-cyclohept[d]isoxazole-7-carboxylic acid of melting point 183°-185° C.

Provenance & Evidence