Water → HCID 19899066, compound

Participants

Reaction Conditions

Reaction Steps

0.286 g (0.00091 mol) of methyl 5,6,7,8-tetrahydro-3-(4-isopropylphenyl)-4H-cyclohept[d]isoxazole-6-carboxylate was dissolved in 15 ml of methanol, 0.15 g (0.0027 mol) of potassium hydroxide and 2 ml of water were added and the mixture was stirred at 20° C. for 68 hours. The methanol was removed by evaporation. Water was added and the mixture was extracted once with diethyl ether. The aqueous layer was acidified with 2N hydrochloric acid and extracted with ethyl acetate. The extract was washed with sodium chloride solution and dried over magnesium sulfate. Evaporation gave a residue which was crystallized from methylcyclohexane to give 200 mg of 5,6,7,8-tetrahydro-3-(4-isopropylphenyl)-4H-cyclohept[d]isoxazole-6-carboxylic acid of melting point 109°-111° C.

Provenance & Evidence