Potassium Hydroxide → HCID 19899097, compound

Participants

Reaction Conditions

Reaction Steps

1 g (3.12 mmol) of methyl 3-(4-chlorophenyl)-5,6,7,8-tetrahydro-6-methyl-4H-cyclohept[d]isoxazole-6-carboxylate was dissolved in 60 ml of methanol and a solution of 0.8 g of potassium hydroxide in 4 ml of water was added. The mixture was stirred at 20° C. for 48 hours and then at 50° C. for 6 hours. The methanol was removed by evaporation. Water was added and the mixture was acidified with 2N hydrochloric acid. The mixture was extracted three times with diethyl ether and the extracts were washed with sodium chloride solution and dried over magnesium sulfate. Evaporation and crystallization of the residue from ethyl acetate/hexane gave 0.594 g of 3-(4-chlorophenyl)-5,6,7,8-tetrahydro-6-methyl-4H-cyclohept[d]isoxazole-6-carboxylic acid of melting point 163° C.

Provenance & Evidence