HCID 67895936, compound → HCID 19899064, compound

Participants

Reaction Conditions

Reaction Steps

3.38 g of methyl 3-(4-trifluoromethylphenyl)-3a,5,6,7,8,8a-hexahydro-8a-pyrrolidino-4H-cyclohept[d]isoxazole-7-carboxylate were dissolved in a mixture of 10 ml of glacial acetic acid, 10 ml of water and 10 ml of concentrated sulfuric acid and heated at 120° C. for 2 hours. The mixture was cooled, diluted with water and extracted three times with 100 ml of methylene chloride each time. The extracts were dried over magnesium sulfate and evaporated and the residue was crystallized from methanol to give 0.32 g of 3-(4-trifluoromethylphenyl)-5,6,7,8-tetrahydro-4H-cyclohept[d]isoxazole-7-carboxylic acid of melting point 222°-225° C.

Provenance & Evidence