HCID 19899051, compound → HCID 19899026, compound

Participants

Reaction Steps

2.32 g (0.006 mol) of methyl 3a,5,6,7,8,8a-hexahydro-3-(4-methoxyphenyl)-8a-pyrrolidino-4H-cyclohept[d]isoxazole-7-carboxylate were dissolved in a mixture of 6 ml of glacial acetic acid, 6 ml of water and 6 ml of concentrated sulfuric acid. The mixture was held at 100° C. for 1 hour, cooled and diluted with 20 ml of water to give a white precipitate which was filtered off, washed and dried. Crystallization from ethyl acetate gave 1.04 g of 5,6,7,8-tetrahydro-3-(4-methoxyphenyl)-4H-cyclohept[d]isoxazole-7-carboxylic acid of melting point 194°-196° C.

Provenance & Evidence