Potassium Hydroxide → HCID 19899088, compound

Participants

Reaction Conditions

Reaction Steps

1.7 g (0.00565 mol) of methyl 5,6,7,8-tetrahydro-3-(4-methoxyphenyl)-4H-cyclohept[d]isoxazole-6-carboxylate were dissolved in 20 ml of methanol. 1 g of potassium hydroxide in 3 ml of water was added and the mixture was stirred at 20° C. for 66 hours. The methanol was removed by evaporation and an excess of water was added. The mixture was acidified with dilute hydrochloric acid and the resulting precipitate was filtered off, washed with water and dried. Crystallization from ethyl acetate/hexane gave 1.1 g of 5,6,7,8-tetrahydro-3-(4-methoxyphenyl)-4H-cyclohept[d]isoxazole-6-carboxylic acid of melting point 147°-148° C.

Provenance & Evidence