Water → HCID 67896241, compound

Participants

Reaction Steps

0.024 g (0.068 mmol) of methyl cis-3-(4-chlorophenyl)-5,6,7,8-tetrahydro-4-methylthio-4H-cyclohept[d]isoxazole-7-carboxylate was stirred in 5 ml of dioxane and 2 ml of 1N aqueous sodium hydroxide solution were added. The mixture was stirred at room temperature for 1 hour. Water was then added and the solution was partially evaporated. The aqueous solution was acidified with 1N hydrochloric acid and the precipitate was collected, washed with water and dried to give 0.0146 g of cis-3-(4-chlorophenyl)-5,6,7,8-tetrahydro-4-methylthio-4H-cyclohept[d]isoxazole7-carboxylic acid of melting point 241°-242° C.

Provenance & Evidence