Hydrochloric Acid → HCID 53856078, compound

Participants

Reaction Steps

0.36 g (1.13 mmol) of methyl trans-3-(4-chlorophenyl)-5,6,7,8-tetrahydro-4-methyl-4H-cyclohept[d]isoxazole-7-carboxylate in 35 ml of dioxane was stirred at room temperature for 1 hour with 15 ml of 1N aqueous sodium hydroxide solution. Water was added and the solution was partially evaporated. Additional water was added to give a solution which was then acidified with 1N hydrochloric acid. The precipitate was filtered off, washed with water and dried to give 0.278 g of trans-3-(4-chlorophenyl)-5,6,7,8-tetrahydro-4-methyl-4H-cyclohept[d]isoxazole-7-carboxylic acid of melting point 154°-155° C.

Provenance & Evidence