HCID 11757738, compound → HCID 15078287, compound

HRID 1196695Notes

Reaction equation

[CH3:1][S:2]([C:5]1[CH:6]=[C:7]([C:23](=[O:40])[CH2:24][CH2:25][C:26]([C:28]2[CH:33]=[C:32]([O:34][CH3:35])[C:31]([O:36][CH3:37])=[C:30]([O:38][CH3:39])[CH:29]=2)=[O:27])[CH:8]=[C:9]([O:15][CH2:16][C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=2)[C:10]=1[O:11][CH2:12][CH2:13][CH3:14])(=[O:4])=[O:3].CS(C1C=C([C@@H](O)CCC(C2C=C(OC)C(OC)=C(OC)C=2)O)C=C(OCC2C=CC=CC=2)C=1OCCC)(=O)=O>>[CH3:1][S:2]([C:5]1[CH:6]=[C:7]([CH:23]([OH:40])[CH2:24][CH2:25][CH:26]([C:28]2[CH:33]=[C:32]([O:34][CH3:35])[C:31]([O:36][CH3:37])=[C:30]([O:38][CH3:39])[CH:29]=2)[OH:27])[CH:8]=[C:9]([O:15][CH2:16][C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=2)[C:10]=1[O:11][CH2:12][CH2:13][CH3:14])(=[O:3])=[O:4]

Participants

Reactant 2

HCID 11757738HCID 11757738, compound

HCID 15078286HCID 15078286, compound

Product 1

HCID 15078287HCID 15078287, compound

Procedure

This compound was prepared from 1-(3-methylsulfonyl-4-n-propoxy-5-benzyloxyphenyl)-4-(3,4,5-trimethoxyphenyl) butan-1,4-dione (STEP D) as shown for (-)-(1S)-1-(3-methylsulfonyl-4-n-propoxy-5-benzyloxyphenyl)-4-(3,4,5-trimethoxyphenyl butan-1-ol-4-one (STEP F) and used without further purification.

Workup

customused without further purification

Sources & evidence

ORD record: ord-8f5d6c8f7d314785995823fa335b8fc0
Source dataset: uspto-grants-1992_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05114961

Reaction notes

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