Oxalate → HCID 19898733, compound

Participants

Reaction Conditions

Reaction Steps

To 2 ml of N,N-dimethylformamide were added 0.78 g of the previously obtained 3-(2,3-dimethyl-4-oxo-4H-1-benzopyran-5-yl)oxypropyl bromide (Compound 6), 0.9 g of 1,3-dimethyl-6-(piperazine-1-yl)-2,4(1H,3H)-pyrimidinedione (Compound 3) and 3 ml of triethylamine, and the solution was then heated at 100° C. for 3 hours in order to carry out reaction. The resultant reaction solution was treated and then purified in the same manner as in Example 1-(2) to obtain 0.96 g (yield 84%) of 1,3-dimethyl-6-(4-[3-(2,3-dimethyl-4-oxo-4H-1-benzopyran-5-yl)oxypropyl]piperazine-1-yl)-2,4(1H,3H)-pyrimidinedione (the non-oxalate of Compound 7).

Provenance & Evidence