Hydrochloric Acid → HCID 19898767, compound

Participants

Reaction Steps

In 50 ml of dioxane, there were heated under reflux for 4 hours 2.12 g of 3-[2-(pyridine-4-yl)-4-oxo-4H-1-benzopyran-5-yl]oxy-1-methanesulfonyloxypropane (Compound 24), 1 ml of triethlamine and 1.95 g of 1,3-dimethyl-6-(piperazine-1-yl)-2,4(1H,3H)-pyrimidinedione (Compound 3). The resultant reaction solution was then concentrated, and the resultant residue was dissolved in chloroform and then washed with water. Afterward, the water-washed chloroform layer was dried over anhydrous sodium sulfate and then purified through a silica gel column chromatograph (chloroform:methanol=100:1 to 100:15 in volume ratio) and then recrystallized from ethanol, thereby obtaining 2.36 g (yield 83%) of 1,3-dimethyl-6-(4-[3-[2-(pyridine-4-yl)-4-oxo-4H-1-benzopyran-5-yl]oxypropyl]pyperazine-1-yl)-2,4(1H,3H)-pyrimidinedione (the non-hydrochloride of Compound 25).

Provenance & Evidence