1,3-Dimethyl-6-(piperazin-1-yl)pyrimidine-2,4(1H,3H)-dione → HCID 19898755, compound

Participants

Reaction Steps

In 30 ml of ethanol, there were heated under reflux for 3 hours 0.88 g of 2-phenyl-5-(2,3-epoxypropoxy)-4-oxo-4H-1-benzopyran (Compound 36) and 0.67 g of 1,3-dimethyl-6-(piperazine-1-yl)-2,4(1H,3H)-pyrimidinedione (Compound 3), and the reaction solution was then concentrated under reduced pressure. The resultant residue was purified through a silica gel column chromatograph (chloroform:methanol=100:1 to 100:5 in volume ratio), and then crystallized from ethyl acetate, thereby obtaining 1.21 g of 1,3-dimethyl-6-(4-[3-(2-phenyl-4-oxo-4H-1-benzopyran-5-yl)oxy-2-hydroxypropyl]piperazine-1-yl)-2,4(1H,3H)-pyrimidinedione (the non-hydrochloride of Compound 37).

Provenance & Evidence