Monomethylamine methanol → HCID 131717389, compound

HRID 1196738Notes

Reaction equation

[NH:1]1[C:45](=[O:46])[C@H:40]([CH2:41][CH:42]([CH3:44])[CH3:43])[NH:39][C:37](=[O:38])[C@@H:33]([CH:34]([CH3:36])[CH3:35])[NH:32][C:30](=[O:31])[C@@H:29]2[CH2:47][CH2:48][CH2:49][N:28]2[C:26](=[O:27])[C@@H:21]([CH2:22][C:23](=[O:25])[OH:24])[NH:20][C:18](=[O:19])[C@H:2]1[CH2:3][C:4]1[C:12]2[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=2)[N:6]([CH2:13][C:14]([O:16]C)=O)[CH:5]=1.[CH3:50][NH2:51].CO>>[NH:1]1[C:45](=[O:46])[C@H:40]([CH2:41][CH:42]([CH3:43])[CH3:44])[NH:39][C:37](=[O:38])[C@@H:33]([CH:34]([CH3:35])[CH3:36])[NH:32][C:30](=[O:31])[C@@H:29]2[CH2:47][CH2:48][CH2:49][N:28]2[C:26](=[O:27])[C@@H:21]([CH2:22][C:23](=[O:25])[OH:24])[NH:20][C:18](=[O:19])[C@H:2]1[CH2:3][C:4]1[C:12]2[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=2)[N:6]([CH2:13][C:14]([NH:51][CH3:50])=[O:16])[CH:5]=1

Participants

Reactant 2

HCID 57454252Monomethylamine methanol

HCID 131717390HCID 131717390, compound

Product 1

HCID 131717389HCID 131717389, compound

Procedure

cyclo(-DTrp(CH2COOCH3)-DAsp-Pro-DVal-Leu-) prepared in Example 90 was allowed to react with 40% methylamine/methanol as the same procedure described in Example 91 to give the title compound.

Sources & evidence

ORD record: ord-72e7fe6002ce445dbdfb4abbb76212a3
Source dataset: uspto-grants-1992_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05114918

Reaction notes

Loading…