Sodium Hydroxide → HCID 131717391, compound

HRID 1196739Notes

Reaction equation

HRID 1196739 reaction equation
[NH:1]1[C:52](=[O:53])[C@H:47]([CH2:48][CH:49]([CH3:51])[CH3:50])[NH:46][C:44](=[O:45])[C@@H:40]([CH:41]([CH3:43])[CH3:42])[NH:39][C:37](=[O:38])[C@@H:36]2[CH2:54][CH2:55][CH2:56][N:35]2[C:33](=[O:34])[C@@H:21]([CH2:22][C:23](=[O:32])[O:24]CC2C=CC=CC=2)[NH:20][C:18](=[O:19])[C@H:2]1[CH2:3][C:4]1[C:12]2[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=2)[N:6]([CH2:13][C:14]([O:16]C)=[O:15])[CH:5]=1.[OH-].[Na+]>CO>[NH:1]1[C:52](=[O:53])[C@H:47]([CH2:48][CH:49]([CH3:50])[CH3:51])[NH:46][C:44](=[O:45])[C@@H:40]([CH:41]([CH3:43])[CH3:42])[NH:39][C:37](=[O:38])[C@@H:36]2[CH2:54][CH2:55][CH2:56][N:35]2[C:33](=[O:34])[C@@H:21]([CH2:22][C:23](=[O:24])[OH:32])[NH:20][C:18](=[O:19])[C@H:2]1[CH2:3][C:4]1[C:12]2[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=2)[N:6]([CH2:13][C:14]([OH:16])=[O:15])[CH:5]=1

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 131717392HCID 131717392, compound

Product 1

HCID 131717391HCID 131717391, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

cyclo(-DTrp(CH2COOCH3)-DAsp(OBzl)-Pro-DVal-Leu-) prepared in Example 90 was hydrolized with 1N NaOH in methanol to give the title compound.

Sources & evidence

ORD record
ord-e68adf1a8cd241ea8c46fbbe798359f3
Source dataset
uspto-grants-1992_05
Patent number
US05114918

Reaction notes

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