2-(4-Fluorophenylmethyl)indene → (2-(4-fluorophenylmethyl)inden-1-yl)-N-(1,1-dimethylethyl)dimethylsilanamine

참여 물질

반응 단계

To a mixture of 2-(4-fluorophenylmethyl)indene (2.21 g, 9.9 mmol) in 45 mL of hexanes were added 6.5 mL of butyl lithium (1.6 M hexane; 10.4 mmol). The mixture was stirred overnight, the mother liquor decanted and the solid dissolved in THF. To this was added N-(1,1-dimethylethyl)dimethylsilanamine chloride (1.80 g, 10.8 mmol) and the reaction heated at reflux for three hours. The volatiles were removed in vacuo, the residue extracted with hexane, filtered and the volatiles removed in vacuo to give 3.39 g (97 percent) of a yellow oil.

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