HuagongsheHuagongshe Chemistry Print Report · For research reference only
N-Formylmethionine → 9-Chloro-21-[2-(formylamino)-4-methylthio-1-oxobutylthio]-11beta,17-dihydroxy-16beta-methylpregna-1,4-diene-3,20-dione
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | N-Formylmethionine | HCID 439750 | — |
| Reactant | 9-Chloro-11beta,17-dihydroxy-16beta-methylpregna-1,4-diene-3,20-dione-21-thiol | HCID 131717397 | — |
| Product | 9-Chloro-21-[2-(formylamino)-4-methylthio-1-oxobutylthio]-11beta,17-dihydroxy-16beta-methylpregna-1,4-diene-3,20-dione | HCID 88395311 | 43.6% |
Reaction Steps
The title compound (0.51 gm) was prepared from 9-chloro-11β,17-dihydroxy-16β-methylpregna-1,4-diene-3,20-dione-21-thiol (0.85 gm) and N-formyl-L-methionine (1.15 gm) in the same manner as in Synthetic Example 1.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05116829 |
| Source dataset | uspto-grants-1992_05 |
| ORD ID | ord-6d80ab57ab4345b2a405521af37f43f7 |
| Source note | uspto-grants-1992_05 |