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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1196825Generated: November 1, 2026

N-Formylmethionine → 6,9-Difluoro-21-[2-(formylamino)-4-methylthio-1-oxobutylthio]-11alpha,17-dihydroxy-16alpha-methylpregna-1,4-diene-3,20-dione

https://huagongshe.com/reaction/1196825

Reaction equation

Participants

RoleNameHCIDCharge
ReactantN-FormylmethionineHCID 439750—
Reactant6,9-Difluoro-11beta,17-dihydroxy-16beta-methylpregna-1,4-diene-3,20-dione-21-thiolHCID 131717399—
Product6,9-Difluoro-21-[2-(formylamino)-4-methylthio-1-oxobutylthio]-11alpha,17-dihydroxy-16alpha-methylpregna-1,4-diene-3,20-dioneHCID 8849424132.8%

Reaction Steps

The title compound (0.027 gm) was prepared from 6,9-difluoro-11β,17-dihydroxy-16β-methylpregna-1,4-diene-3,20-dione-21-thiol (0.06 gm) and (N-formyl-L-methionine (0.175 gm) in the same manner as in Synthetic Example 1.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS05116829
Source datasetuspto-grants-1992_05
ORD IDord-81cc4f1dfaa84af6b6957e9be8bb3152
Source noteuspto-grants-1992_05