HuagongsheHuagongshe Chemistry Print Report · For research reference only
N-Formylmethionine → 9-Fluoro-21-[2-(formylamino)-4-methylthio-1-oxobutylthio]-11beta-hydroxy-16beta-methyl-17-(1-oxopentyloxy)-pregna-1,4-diene-3,20-dione
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | N-Formylmethionine | HCID 439750 | — |
| Reactant | 9-Fluoro-11-hydroxy-16beta-methyl-17-(1-oxopentyloxy)-pregna-1,4-diene-3,20-dione-21-thiol | HCID 131717400 | — |
| Product | 9-Fluoro-21-[2-(formylamino)-4-methylthio-1-oxobutylthio]-11beta-hydroxy-16beta-methyl-17-(1-oxopentyloxy)-pregna-1,4-diene-3,20-dione | HCID 88395357 | 16.2% |
Reaction Steps
The title compound (1.03 gm) was prepared from 9-fluoro-11 -hydroxy-16β-methyl-17-(1-oxopentyloxy)-pregna-1,4-diene-3,20-dione-21-thiol (4.80 gm) and N-formyl-L-methionine (6.15 gm) in the same manner as in Synthetic Example 1.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05116829 |
| Source dataset | uspto-grants-1992_05 |
| ORD ID | ord-650ac7d3b62c4ae7a701a013a1ba783b |
| Source note | uspto-grants-1992_05 |