HuagongsheHuagongshe Chemistry Print Report · For research reference only
Tixocortol → 21-[2-(Formylamino)-4-methylthio-1-oxobutylthio]-11beta,17-dihydroxy-pregna-4-ene-3,20-dione
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Tixocortol | HCID 162955 | — |
| Reactant | N-Formylmethionine | HCID 439750 | — |
| Product | 21-[2-(Formylamino)-4-methylthio-1-oxobutylthio]-11beta,17-dihydroxy-pregna-4-ene-3,20-dione | HCID 88395324 | 26.7% |
Reaction Steps
The title compound (0.38 gm) was prepared from 11β,17-dihydroxy-pregna-4-ene-3,20-dione-21-thiol (1.00 gm) and N-formyl-L-methionine (1.41 gm) in the same manner as in Synthetic Example 1.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05116829 |
| Source dataset | uspto-grants-1992_05 |
| ORD ID | ord-0f36832065574788b46c17bfd034e6c2 |
| Source note | uspto-grants-1992_05 |