Back
HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1196828Generated: October 31, 2026

N-Formylmethionine → 9-Fluoro-21-[2-(formylamino)-4-methylthio-1-oxobutylthio]-11beta-hydroxy-16beta-methyl-17-(1-oxopropyloxy)-pregna-1,4-diene-3,20-dione

https://huagongshe.com/reaction/1196828

Reaction equation

Participants

RoleNameHCIDCharge
ReactantN-FormylmethionineHCID 439750—
Reactant9-Fluoro-11 hydroxy-16beta-methyl-17-(1-oxopropyloxy)-pregna-1,4-diene-3,20-dione-21-thiolHCID 131717401—
Product9-Fluoro-21-[2-(formylamino)-4-methylthio-1-oxobutylthio]-11beta-hydroxy-16beta-methyl-17-(1-oxopropyloxy)-pregna-1,4-diene-3,20-dioneHCID 8849396143.8%

Reaction Steps

The title compound (0.47 gm) was prepared from 9-fluoro-11 hydroxy-16β-methyl-17-(1-oxopropyloxy)-pregna-1,4-diene-3,20-dione-21-thiol (0.80 gm) and N-formyl-L-methionine (0.99 gm) in the same manner as in Synthetic Example 1.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS05116829
Source datasetuspto-grants-1992_05
ORD IDord-757afafb28134c37ba2099f58ecb7455
Source noteuspto-grants-1992_05