HRID1196832

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID147382

L-Cysteine, N-acetyl-S-ethyl-

C7H13NO3S

结构：C[C@H]1C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@]4(C)[C@@]3(F)C(O)C[C@]2(C)[C@@]1(O)C(=O)CS

HCID131717402

未命名化合物

PRODUCTS

生成物

结构：CCSCC(NC(C)=O)C(=O)SCC(=O)[C@@]1(O)[C@@H](C)C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@]4(C)[C@@]3(F)[C@@H](O)C[C@@]21C

HCID88395374

未命名化合物

收率 29.5%

PROCEDURE

实验过程

The title compound (0.21 gm) was prepared from 9-fluoro-11 ,17-dihydroxy-16β-methylpregna-1,4-diene-3,20-dione-21-thiol (0.5 gm) and N-acetyl-S-ethylcysteine (0.70 gm) in the same manner as in Synthetic Example 1.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-8cb11f885d7e46b78341dadba13e2a42
来源数据集: uspto-grants-1992_05
DOI: 10.6084/m9.figshare.5104873.v1
专利: US05116829
来源说明: uspto-grants-1992_05

反应 SMILES

[F:1][C@:2]12[CH:22]([OH:23])[CH2:21][C@@:20]3([CH3:24])[C@@H:12]([CH2:13][C@H:14]([CH3:26])[C@:15]3([OH:25])[C:16](=[O:19])[CH2:17][SH:18])[C@@H:11]1[CH2:10][CH2:9][C:8]1[C@:3]2([CH3:28])[CH:4]=[CH:5][C:6](=[O:27])[CH:7]=1.[C:29]([NH:32][C@H:33]([C:38](O)=[O:39])[CH2:34][S:35][CH2:36][CH3:37])(=[O:31])[CH3:30]>>[C:29]([NH:32][CH:33]([CH2:34][S:35][CH2:36][CH3:37])[C:38](=[O:39])[S:18][CH2:17][C:16](=[O:19])[C@:15]1([OH:25])[C@:20]2([CH3:24])[C@H:12]([C@H:11]3[C@:2]([F:1])([C@@H:22]([OH:23])[CH2:21]2)[C@:3]2([CH3:28])[C:8](=[CH:7][C:6](=[O:27])[CH:5]=[CH:4]2)[CH2:9][CH2:10]3)[CH2:13][C@@H:14]1[CH3:26])(=[O:31])[CH3:30]