Hydrochloric Acid → HCID 53923971, compound

Participants

Reaction Steps

To a solution of 0.25 g of 17β-tetrahydropyranyloxy-5α-estr-2-en, Compound 4, in 8 ml of methanol is added 1N hydrochloric acid (0.2 ml) and the reaction mixture is stirred at room temperature for 6 hr. Evaporation of the solvent under vacuum produces a residue of white crystals. The residue is treated with water (15 ml) and ether (25 ml). The ether phase is separated, and the water is extracted once more with 12 ml of ether. The combined ether phase is washed with water, sodium chloride solution, and dried over sodium sulfate. Evaporation of the solvent produces 0.19 g of 17β-hydroxy-5α-estr-2-ene. The structure of the Compound 5, is confirmed by the following spectral data:

Provenance & Evidence