Acetyl chloride → HCID 19896706, compound

HRID 1196843Notes

Reaction equation

HRID 1196843 reaction equation
[O:1]=[C:2]([C:9]1[CH:19]=[CH:18][C:12]2[NH:13][C:14](=[O:17])[CH2:15][O:16][C:11]=2[CH:10]=1)[CH:3]([CH3:8])[CH2:4][C:5]([OH:7])=[O:6].[C:20](Cl)(=O)C>CO>[O:1]=[C:2]([C:9]1[CH:19]=[CH:18][C:12]2[NH:13][C:14](=[O:17])[CH2:15][O:16][C:11]=2[CH:10]=1)[CH:3]([CH3:8])[CH2:4][C:5]([O:7][CH3:20])=[O:6]

Participants

4

Reactant 2

HCID 6367Acetyl chlorideHCID 11065271HCID 11065271, compound

Product 1

HCID 19896706HCID 19896706, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

4-Oxo-4-(3,4-dihydro-3-oxo-2H-1,4-benzoxazin-7-yl)-3-methylbutyric acid (5 g) was suspended in methanol (50 ml) and acetyl chloride (0.5 ml) added. The mixture was heated on a steam bath until all of the solid dissolved. The solvent was evaporated at reduced pressure providing the ester as a white foam which was recrystallized from ethyl acetate-methanol to give the product as white crystals, yield 5 g, mp 95°-98° C.

Workup

  1. temperatureThe mixture was heated on a steam bath until all of the solid
  2. dissolutiondissolved
  3. customThe solvent was evaporated at reduced pressure

Sources & evidence

ORD record
ord-3d2074996cfc4092bb469946b1b5537e
Source dataset
uspto-grants-1992_05
Patent number
US05116837

Reaction notes

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