1,4-Dioxane hydrochloride → 3-(2-Hydroxy-3-morpholinopropoxy)-5-phenylisoxazole hydrochloride

Participants

Reaction Steps

To a solution of 5.00 g of 3-(2-hydroxy-3-morpholinopropoxy-5-phenylisoxazole dissolved in ethyl acetate (200 ml) was added a 4N HCl/dioxane solution (5.0 ml) and the mixture was stirred at room temperature for 10 minutes. The reaction mixture was concentrated under reduced pressure to afford 5.21 g of the title compound with melting point 149°-150° C. as colorless powdery crystals.

Provenance & Evidence