4-Nitrobenzyl alcohol → HCID 19896605, compound

Participants

Reaction Steps

A solution of p-(methylthio)benzyl alcohol (1.0 g, 6.48 mmol), carbonyl diimidazole (1.16 g, 7.13 mmol) and sodium imidazole (0.010 g) in CH3CN (25 mL) was stirred at 20° C. for 30 min, followed by addition of p-nitrobenzyl alcohol (1.09 g, 7.13 mmol). Stirring was continued for an additional 24 h and then the reaction mixture was evaporated to dryness. The crude carbonate was purified by silica gel chromatography (eluted with CH2Cl2) to afford 2.13 g (98.6%) of the title compound as a white solid, melting at 84°-86° C.

Provenance & Evidence