HCID 14209951, compound → HCID 14209957, compound

Participants

Reaction Steps

2.4 g. (7.7 mmole) 6-isonicotinoylamino-7-nitro-1,2,3,4-tetrahydroquinolin-2-one were hydrogenated in 100 ml. methanol in the presence of 0.4 g. 10% palladium on charcoal. After filtering off the catalyst and evaporating the filtrate, the residue was boiled for 24 hours with 80 ml. ethanol and 15 ml. concentrated hydrochloric acid. The evaporation residue was treated with water and ammonia, filtered off with suction and recrystallized from methanol to give 1.3 g. (62% of theory) of the title compound; m.p. above 300° C.

Provenance & Evidence