1H-indole-2-carbonyl Chloride → HCID 19896780, compound

HRID 1196902Notes

Reaction equation

HRID 1196902 reaction equation
[NH:1]1[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[CH:3]=[C:2]1[C:10](Cl)=O.[CH3:13][C:14]1([CH3:27])[C:23]2[C:18](=[CH:19][C:20]([NH2:25])=[C:21]([NH2:24])[CH:22]=2)[NH:17][C:16](=[O:26])[CH2:15]1>>[CH3:13][C:14]1([CH3:27])[C:23]2[CH:22]=[C:21]3[NH:24][C:10]([C:2]4[NH:1][C:9]5[C:4]([CH:3]=4)=[CH:5][CH:6]=[CH:7][CH:8]=5)=[N:25][C:20]3=[CH:19][C:18]=2[NH:17][C:16](=[O:26])[CH2:15]1

Participants

3

Reactant 2

HCID 118162081H-indole-2-carbonyl ChlorideHCID 19896766HCID 19896766, compound

Product 1

HCID 19896780HCID 19896780, compoundYield 45%

Procedure

In a manner analogous to that described in Example 2, from indole-2-carboxylic acid chloride and 4,4-dimethyl-6,7-diamino-1,2,3,4-tetrahydroquinolin-2-one (see Example 13 a)), after column chromatography, there was obtained a yield of 45% of theory of the title compound; m.p. 264°-267° C.

Sources & evidence

ORD record
ord-4aa43a9817624399a993d2631c5e3447
Source dataset
uspto-grants-1992_05
Patent number
US05116843

Reaction notes

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