Maleic Acid → HCID 10320318, compound

Participants

Reaction Steps

A saturated solution of maleic acid in ether (20 mL) was added to a solution of 1-benzyl-4-(2-(4''-fluorophenyl)-2'-oxoethyl)piperidine (186 mg, 0.59 mmol) in ether (10 mL) with stirring. The white precipitate was filtered and washed with copious amounts of ether. Drying in vacuo afforded a white powder (284 mg):mp 106°-108° C.; 1H-NMR:12.2-12.0(m,1H), 8.0(dd,2H,J=8,6), 7.5-7.35(m,5H), 7.15(t,2H,J=8), 6.4(s,2H), 4.2(s,2H), 3.65-3.4(m,2H), 2.95(d,2H,J=6), 2.9-2.7(m,2H), 2.4-1.6(m,4H); Anal.:Calcd for C20H22FNO.C4H4O4 0.25H2O:C,66.73, H,6.18, N,3.24; Found:C,66.50, H,5.97, N,3.10.

Provenance & Evidence