HuagongsheHuagongshe Chemistry Print Report · For research reference only
Diisopropylamine → Lithium diisopropylamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Diisopropylamine | HCID 7912 | — |
| Reactant | 4-Ethylpyridine | HCID 10822 | — |
| Reactant | 2-Chloro-1-(2,4-difluorophenyl)ethanone | HCID 588083 | — |
| Reactant | Butyllithium | HCID 178418339 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Solvent | Hexane | HCID 8058 | — |
| Product | Lithium diisopropylamide | HCID 2724682 | — |
| Product | 2-(2,4-Difluorophenyl)-2-(1-[pyridin-4-yl]ethyl)oxirane | HCID 18956530 | — |
Reaction Steps
Lithium diisopropylamide was prepared by addition of n-butyllithium (19.7 ml of a 1.6M solution in hexane) to a solution of diisopropylamine (3.18 g) in dry tetrahydrofuran (50 ml), and the resulting solution was treated successively with 4-ethylpyridine (3.37 g) and a solution of 2-chloro-2',4'-difluoroacetophenone (5.00 g) in dry tetrahydrofuran (50 ml) according to the method of Example 1(i). Work-up of the reaction mixture as before afforded the title compound (1.05 g) as a yellow oil which was used directly in the next stage.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05116844 |
| Source dataset | uspto-grants-1992_05 |
| ORD ID | ord-3fff3c09df244622a74c8f0a275e1f53 |
| Source note | uspto-grants-1992_05 |